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Daniel T Connolly Selected Research

Niacin (Nicotinic Acid)

8/2012Niacin lipid efficacy is independent of both the niacin receptor GPR109A and free fatty acid suppression.
4/2012(1aR,5aR)1a,3,5,5a-Tetrahydro-1H-2,3-diaza-cyclopropa[a]pentalene-4-carboxylic acid (MK-1903): a potent GPR109a agonist that lowers free fatty acids in humans.
10/2008Effects of a niacin receptor partial agonist, MK-0354, on plasma free fatty acids, lipids, and cutaneous flushing in humans.
8/20083-(1H-tetrazol-5-yl)-1,4,5,6-tetrahydro-cyclopentapyrazole (MK-0354): a partial agonist of the nicotinic acid receptor, G-protein coupled receptor 109a, with antilipolytic but no vasodilatory activity in mice.
6/2007Nicotinic acid receptor agonists differentially activate downstream effectors.
4/2007Analogues of acifran: agonists of the high and low affinity niacin receptors, GPR109a and GPR109b.
12/2006Langerhans cells release prostaglandin D2 in response to nicotinic acid.

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Daniel T Connolly Research Topics

Disease

5Flushing
08/2012 - 12/2006
3Atherosclerosis
06/2007 - 12/2006
2Thrombosis (Thrombus)
06/2010 - 05/2008
1Dyslipidemias (Dyslipidemia)
04/2012
1Myocardial Infarction
01/2012

Drug/Important Bio-Agent (IBA)

7Niacin (Nicotinic Acid)FDA LinkGeneric
08/2012 - 12/2006
2ProstaglandinsIBA
08/2012 - 12/2006
2LipidsIBA
04/2012 - 10/2008
2HDL CholesterolIBA
10/2008 - 06/2007
2Prostaglandin D2IBA
08/2008 - 06/2007
1GTP-Binding Proteins (G-Protein)IBA
01/2012
1APD791IBA
06/2010
15-HT2A Serotonin Receptor (5 HT2A Receptor)IBA
06/2010
1Serotonin (5 Hydroxytryptamine)IBA
06/2010
1Nonesterified Fatty Acids (NEFA)IBA
10/2008
1LDL CholesterolIBA
10/2008
13- (1H- tetrazol- 5- yl)- 1,4,5,6- tetrahydrocyclopentapyrazoleIBA
10/2008
1Triglycerides (Triacylglycerol)IBA
10/2008
1AR 246686IBA
05/2008
1Mitogen-Activated Protein KinasesIBA
06/2007
1pyrazoleIBA
06/2007
1Prostaglandins DIBA
12/2006